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CIITA-Tax interaction might differently affectTax-mediated activation of the viral LTR promoter. (A) In the absence of CIITA, Tax-1 is recruited by CREB to the viral LTR and promote the formation of an higher order multiprotein complex activating transcription. (B) CIITA binds Tax and prevents its recruitment to the LTR promoter. (C) Tax bound to CIITA is recruited to the LTR, but its transcription function is impaired.
