Table 7. Statistically overrepresented cyanomyovirus genes in a comparison of the North Pacific Gyre (HOT) and the Mediterranean Sea (MedDCM).
| PhCOG | Bonferroni adjusted Fisher score | HOT | MedDCM | ProPortal description | Overrepresented at | Sig. core? | In host? | Pfam domain | Pfam domain annotation |
|---|---|---|---|---|---|---|---|---|---|
| PhCOG72964 | 1.22E-45 | 653 | 124 | Baseplate wedge initiator protein | HOT | ||||
| PhCOG258 | 5.58E-38 | 2 | 110 | Hypothetical | MedDCM | ||||
| PhCOG969 | 8.40E-30 | 2 | 89 | G6PDH | MedDCM | Y | PF02781/PF00479 | Glucose-6-phosphate dehydrogenase, C-terminal domain/glucose-6-phosphate dehydrogenase, NAD-binding domain | |
| PhCOG964 | 1.79E-27 | 2 | 83 | 6PGDH | MedDCM | PF03446/PF00393/PF03807 | NAD-binding domain of 6-phosphogluconate dehydrogenase/6-phosphogluconate dehydrogenase, C-terminal domain/NADP oxidoreductase coenzyme F420-dependent | ||
| PhCOG73281 | 2.22E-23 | 297 | 48 | Hypothetical | HOT | ||||
| PhCOG2105 | 3.16E-20 | 431 | 108 | Glycine dehydrogenase | HOT | Y | PF02347/PF01212 | Glycine cleavage system P-protein/beta-eliminating lyase | |
| PhCOG71491 | 1.64E-18 | 299 | 60 | DNA adenine methylase | HOT | PF01555 | DNA methylase | ||
| PhCOG97 | 1.24E-15 | 924 | 928 | VrlC | MedDCM | ||||
| PhCOG72264 | 3.36E-15 | 1 | 48 | Hypothetical | MedDCM | ||||
| PhCOG2051 | 7.01E-15 | 110 | 6 | Hypothetical | HOT | ||||
| PhCOG72516 | 2.73E-14 | 0 | 42 | Hypothetical | MedDCM | ||||
| PhCOG72672 | 1.38E-13 | 148 | 233 | Tail sheath monomer | MedDCM | PF04984 | Phage tail sheath protein | ||
| PhCOG71457 | 2.03E-12 | 153 | 22 | Hypothetical | HOT | Y | |||
| PhCOGOrphan_1323 | 2.27E-12 | 94 | 170 | Hypothetical | MedDCM | ||||
| PhCOGOrphan_12 | 2.42E-12 | 102 | 7 | Phage tail fiber-like protein | HOT | ||||
| PhCOG71083 | 2.25E-10 | 65 | 1 | Hypothetical | HOT | ||||
| PhCOGOrphan_404 | 6.41E-10 | 0 | 31 | Hypothetical | MedDCM | ||||
| PhCOGOrphan_1324 | 7.25E-10 | 6 | 46 | Hypothetical | MedDCM | ||||
| PhCOG71124 | 1.09E-09 | 150 | 27 | Phycoerythrobilin | HOT | PF05996 | Ferredoxin-dependent bilin reductase | ||
| PhCOG73276 | 2.23E-09 | 107 | 13 | Hypothetical | HOT | ||||
| PhCOG96 | 6.69E-09 | 135 | 194 | Base plate wedge | MedDCM | PF09215 | Bacteriophage T4, Gp8 | ||
| PhCOG73152 | 1.88E-08 | 77 | 133 | PstS | MedDCM | Y | PF01547 | Bacterial extracellular solute-binding protein | |
| PhCOG1139 | 2.49E-08 | 0 | 27 | Hypothetical | MedDCM | ||||
| PhCOG2 | 3.34E-08 | 905 | 832 | Ribonucleotide reductase A subunit | MedDCM | Y | PF02867/PF00317/PF03477 | Ribonucleotide reductase, barrel domain/ribonucleotide reductase, all-alpha domain/ATP cone domain | |
| PhCOG72825 | 4.52E-08 | 131 | 24 | Hypothetical | HOT | ||||
| PhCOG73058 | 1.34E-07 | 109 | 17 | T4-like base plate hub and tail lysozyme | HOT | ||||
| PhCOG73171 | 1.05E-06 | 47 | 1 | NifU-like protein | HOT | Y | |||
| PhCOG1447 | 1.28E-06 | 42 | 86 | RNaseH | MedDCM | ||||
| PhCOG564 | 4.06E-06 | 397 | 154 | Phage tail fiber-like protein | HOT | ||||
| PhCOGOrphan_1292 | 4.72E-06 | 4 | 31 | Hypothetical | MedDCM | ||||
| PhCOG1681 | 5.31E-06 | 68 | 7 | Hypothetical | HOT | ||||
| PhCOG71433 | 5.49E-06 | 13 | 46 | Plastocyanin | MedDCM | Y | PF00127 | Copper-binding proteins, plastocyanin/azurin family | |
| PhCOG72321 | 5.80E-06 | 39 | 79 | Precursor of major head subunit | MedDCM | PF07068 | Major capsid protein Gp23 | ||
| PhCOGOrphan_394 | 6.01E-06 | 0 | 21 | Hypothetical | MedDCM | ||||
| PhCOG71750 | 6.38E-06 | 101 | 18 | gp7 | HOT | ||||
| PhCOG71460 | 1.04E-05 | 12 | 44 | Hypothetical | MedDCM | ||||
| PhCOGOrphan_657 | 1.37E-05 | 29 | 66 | Phage tail fiber-like protein | MedDCM | ||||
| PhCOG71159 | 1.42E-05 | 55 | 4 | Heme oxygenase | HOT | Y | |||
| PhCOG71555 | 2.40E-05 | 438 | 181 | Photosystem II D1 protein | HOT | Y | Y | PF00124 | Photosynthetic reaction center protein |
| PhCOG71986 | 3.74E-05 | 0 | 19 | Antioxidant protein | MedDCM | Y | |||
| PhCOG72368 | 3.74E-05 | 0 | 19 | Hypothetical | MedDCM | ||||
| PhCOG72879 | 1.25E-04 | 57 | 6 | Hypothetical | HOT | ||||
| PhCOG73056 | 1.98E-04 | 41 | 2 | Phage tail fiber-like protein | HOT | ||||
| PhCOG72250 | 2.33E-04 | 0 | 17 | Hypothetical | MedDCM | ||||
| PhCOG71068 | 2.74E-04 | 36 | 1 | Hypothetical | HOT | ||||
| PhCOG73044 | 2.80E-04 | 103 | 23 | Phage tail fiber-like protein | HOT | ||||
| PhCOG73097 | 3.61E-04 | 59 | 92 | Carbamoyltransferase | MedDCM | ||||
| PhCOGOrphan_658 | 3.82E-04 | 7 | 31 | Hypothetical | MedDCM | ||||
| PhCOG2016 | 5.10E-04 | 29 | 0 | Hypothetical | HOT | Y | |||
| PhCOGOrphan_620 | 5.35E-04 | 91 | 19 | Hypothetical | HOT | ||||
| PhCOG1098 | 5.81E-04 | 0 | 16 | Hypothetical | MedDCM | ||||
| PhCOG73282 | 6.19E-04 | 71 | 12 | Base plate wedge | HOT | ||||
| PhCOG456 | 1.45E-03 | 0 | 15 | Hypothetical | MedDCM | Y | |||
| PhCOG72627 | 1.45E-03 | 0 | 15 | PhoA | MedDCM | ||||
| PhCOG739 | 1.45E-03 | 0 | 15 | Hypothetical | MedDCM | ||||
| PhCOG71169 | 1.74E-03 | 228 | 84 | Hypothetical | HOT | ||||
| PhCOG72664 | 1.90E-03 | 4 | 24 | Hypothetical | MedDCM | ||||
| PhCOG224 | 1.94E-03 | 94 | 22 | Hypothetical | HOT | ||||
| PhCOG1544 | 3.62E-03 | 0 | 14 | Hypothetical | MedDCM | ||||
| PhCOG963 | 4.59E-03 | 38 | 3 | Hypothetical | HOT | ||||
| PhCOG4516 | 4.85E-03 | 166 | 56 | Hypothetical | HOT | ||||
| PhCOG72163 | 5.12E-03 | 641 | 560 | Base plate wedge | MedDCM | Y | |||
| PhCOG72041 | 8.20E-03 | 11 | 32 | Phosphoribosylaminoimidazole-succinocarboxamide synthase | MedDCM | Y | PF01259 | SAICAR synthetase | |
| PhCOG529 | 9.02E-03 | 0 | 13 | Hypothetical | MedDCM | Y |
Abbreviations: ATP, adenosine triphosphate; NAD, nicotinamide adenine dinucleotide; NADP, NAD phosphate; SAICAR, phosphoribosylaminoimidazolesuccinocarboxamide.