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. 2001 Jul 3;98(15):8680–8685. doi: 10.1073/pnas.151180898

Figure 4.

Figure 4

Nuclear translocation of Stat3 is attenuated in LIF −/− mice. (A) Stat3 immunoreactivity in uterine sections reveals a uniform nuclear localization of Stat3 to the entire LE on day 4 in +/+ but not −/− mice. (B) Higher-powered views are shown for days 3–5 of Stat3 localization to the LE and GE nuclei. (C) A summary table of the stained uterine sections is shown where the number of uteri showing predominant cytoplasmic localization (c > n) of Stat3 or nuclear localization (c < n) is presented in both the LE and GE. A few day-3 +/+ sections showed occasional nuclear translocation of Stat3 in both LE and GE. In day-3 LIF −/−, no translocation was evident. In D4 +/+, more than half of the uteri showed complete nuclear localization of Stat3 in the entire LE but not in GE. In contrast, LIF −/− uteri showed little or no nuclear localization in the LE. In day-5 +/+ animals, the nuclear localization of Stat3 in LE is absent in the LE between implantation sites with some nuclear staining detected in GE. LIF −/− mice show a marked reduction and absence of Stat3 nuclear location in both LE and GE. WT, wild type.