Table 2. Age-adjusted ORs of cumulative risk of selected type-specific HPV infections according to putative TLR9 phenotype.
Significant associations are highlighted in bold.
| Genotype/species | HPV-positive vs random sample of HPV-negative women | HPV-positive vs HPV-negative who completed a minimum of ten visits | ||
| Dominant model* | Recessive model† | Dominant model* | Recessive model† | |
| OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | OR (95 % CI) | |
| HPV genotype | ||||
| 6/11 | 1.82 (0.99–3.32) | 1.53 (0.44–5.27) | 1.88 (1.02–3.44) | 1.59 (0.46–5.56) |
| 16 | 0.88 (0.58–1.34) | 1.02 (0.38–2.71) | 0.87 (0.57–1.33) | 1.05 (0.39–2.84) |
| 18 | 0.63 (0.30–1.34) | na | 0.63 (0.30–1.34) | na |
| 31 | 0.89 (0.44–1.79) | na | 0.92 (0.45–1.86) | na |
| 35 | 2.38 (1.12–5.06) | 0.77 (0.10–5.88) | 2.37 (1.11–5.04) | 0.79 (0.10–6.06) |
| 45 | 0.91 (0.44–1.88) | 2.26 (0.65–7.89) | 0.92 (0.44–1.92) | 2.35 (0.67–8.31) |
| 51 | 0.89 (0.50–1.56) | 1.24 (0.36– 4.23) | 0.89 (0.50–1.57) | 1.29 (0.37–4.42) |
| 52 | 0.79 (0.42–1.51) | 1.01 (0.23–4.36) | 0.79 (0.42–1.51) | 1.03 (0.24–4.53) |
| 53 | 1.11 (0.68–1.83) | 0.29 (0.04–2.17) | 1.09 (0.66–1.79) | 0.30 (0.04–2.21) |
| 54 | 1.58 (0.82–3.07) | 0.60 (0.08–4.55) | 1.55 (0.80–3.01) | 0.62 (0.08–4.66) |
| 55 | 1.56 (0.86–3.20) | 1.96 (0.57–6.75) | 1.66 (0.86–3.20) | 2.03 (0.58–7.05) |
| 56 | 2.10 (0.97–4.55) | 0.85 (0.11–6.47) | 2.05 (0.95–4.46) | 0.87 (0.11–6.65) |
| 58 | 0.77 (0.40–1.48) | 0.50 (0.07–3.78) | 0.76 (0.40–1.47) | 0.51 (0.07–3.89) |
| 59 | 1.37 (0.60–3.10) | 0.92 (0.12–7.06) | 1.40 (0.61–3.17) | 0.95 (0.12–7.33) |
| 61 | 0.59 (0.24–1.42) | 4.43 (1.43–13.72) | 0.58 (0.24–1.40) | 4.60 (1.48–14.36) |
| 68 | 1.66 (0.76–3.62) | 3.07 (0.87–10.80) | 1.63 (0.75–3.58) | 3.17 (0.89–11.24) |
| 73 | 0.34 (0.13–0.91) | na | 0.34 (0.13–0.89) | na |
| 84 | 1.33 (0.76–2.33) | 1.34 (0.40–4.54) | 1.30 (0.75–2.28) | 1.38 (0.40–4.70) |
| 89 | 4.90 (0.98–24.48) | 3.14 (0.37–26.41) | 4.96 (0.99–24.78) | 3.24 (0.38–27.36) |
| Any HPV | 0.94 (0.70–1.27) | 0.63 (0.31–1.27) | 0.87 (0.63–1.20) | 0.62 (0.29–1.32) |
| Alphapapillomavirus species‡ | ||||
| Species 3 | 1.15 (0.79–1.68) | 1.27 (0.54–2.99) | 1.12 (0.77–1.65) | 1.32 (0.55–3.14) |
| Species 7 | 1.16 (0.78–1.70) | 1.08 (0.43–2.68) | 1.15 (0.78–1.71) | 1.11 (0.44–2.81) |
| Species 9 | 0.92 (0.67–1.27) | 1.02 (0.48–2.20) | 0.90 (0.65–1.25) | 1.06 (0.48–2.34) |
| Species 10 | 1.67 (1.05–2.66) | 1.50 (0.56–4.02) | 1.69 (1.06–2.71) | 1.56 (0.57–4.26) |
OR, odds ratio; CI, confidence interval; na, Not applicable.
*
Dominant model: mutant homozygote (CC)+heterozygote (TC) versus WT homozygote (TT).
†
Recessive model: WT homozygote (TT)+heterozygote (TC) versus mutant homozygote (CC).
‡
Species 3 (HPV61, -72, -62, -81, -83, -84 and -89); species 7 (HPV18, -39, -45, -59, -68 and -70); species 9 (HPV16, -31, -33, -35, -52, -58 and -67); species 10 (HPV6, -11, -44 and -55).