Table 2.
Genes down regulated during HBV induced hepatocellular carcinoma
| Genes Down regulated during HCC: | ||||
|---|---|---|---|---|
| Gene | Gene name | Activated by | Function | Reference |
| BID | BH3 interacting domain | HBx protein | Cell death regulation | [106] |
| P53 | Protein 53 | HBx | Tumor suppressor | [107] |
| p21WAF1 | Protein 21 | HBx | Stress response, acts with p53 | [107] |
| IGFBP3 | Insulin-like growth factor-binding protein 3 | HBx | [107] | |
| CASP8 | Caspase 8 | HBV | Apoptosis-related cysteine peptidase | [89] |
| CDKN1A/p21 | Cyclin-dependent kinase inhibitor 1A | HBV | Inhibits the activity of cyclin-CDK2 | [107] |
| DLC1 | Deleted in liver cancer 1 | HBV | Tumor suppressor, cell growth, and proliferation | [108] |
| FADD | Fas-associated protein with death domain | HBV | Adaptor molecule that bridges the Fas-receptor | [109] |
| IGFBP1 | Insulin-like growth factor-binding protein 1 | HBV | Tumor suppressor | [110] |
| ITGB1 | Integrins beta 1 | HBV | Embryogenesis, hemostasis, tissue repair, immune response | [111] |
| Hhip | Hh-interacting protein | HBV | Modulates hedgehog signaling | [112] |
| PTEN | HBV | Apoptosis, cell movement | [113] | |
| RB1 | Retinoblastoma 1 | HBV | Oncogenic, tumor suppressor | [114] |
| SMAD4 | HBV | Transmitting chemical signal, regulates cell growth and division | [115] | |
| SOCS1 | Suppressor of cytokine signaling 1 | HBV | Negative regulator in TNF-induced inflammation and activation of c-jun N-terminal kinase | [116] |
| SOCS3 | Suppressor of cytokine signaling 3 | HBV | [117] | |
| TGFBR2 | Transforming growth factor, beta receptor II | HBV | Transmits signals, stimulation of cell growth and division, differentiation | [118] |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | HBV and HCV | Cell cycle control, tumor suppressor gene | [119] |