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. 2013 Aug 6;109(4):1056–1062. doi: 10.1038/bjc.2013.336

Figure 5.

Figure 5

Designing evolutionarily stable anti-growth factor treatments. At generation 1000, a drug is introduced that increases the threshold h from 0.1 to h*, in t generations. n=50; c=0.01; s=0.2. (A) h*=0.9; variable t, from 5 to 100 generations. If the transition is not fast enough, producers reach a new equilibrium (here, the transition must occur in 20 generations or less). (B) t=20; variable h*, from 0.3 to 0.98. If the treatment does not reduce enough the available amount of growth factor, producers reach a new equilibrium (here, the reduction must be strong enough to change the threshold from 0.1 to at least 0.9).