Table 1. Patient characteristics.
All patients | |
---|---|
|
N=87 (%/range) |
Median age |
56 (27–80) |
Tumour type | |
Ovarian epithelial | 80 (92.0) |
Fallopian tube | 2 (2.3) |
Primary peritoneal |
5 (5.7) |
Stage | |
II | 5 (5.7) |
III | 48(55.2) |
IV |
34 (39.1) |
BRCA mutation statusa | |
BRCA1 | 44 (50.6) |
BRCA2 | 12 (13.8) |
Any BRCA mutation | 56 (64.4) |
Negative |
31 (35.6) |
History of allergy to medications, environmental factors, foods, and type IV contrast |
44 (50.6) |
Median platinum-free interval in months |
15.9 (5.7–82.4) |
Median number of prior carboplatin regimens |
2 (0–6) |
Median number of prior carboplatin cycles |
9 (0–42) |
Median number of prior platinum regimensb |
2 (1–6) |
Median number of prior platinum cyclesb | 12 (2–42) |
One patient had both BRCA1 and 2 mutation and is counted once in ‘any BRCA mutation' cohort; one patient had a BRCAPro of 68% and is counted in ‘any BRCA mutation' cohort, but not in either of ‘BRCA1' or ‘BRCA2' cohorts.
Includes both carboplatin and cisplatin chemotherapy. One patient received 3 months of oxaliplatin/gemcitabine/cyclophosphamide therapy before enrolment of our trial, but details were not available and excluded from the total platinum calculations.