Table 2. On-study HSR reaction characteristics.

	HSR on study
	N=18 (%/range)
Grade
1	6 (33.3)
2	7 (38.9)
3	5 (27.8)
Symptoms
Pruritus	16 (88.9)
Rash	14 (77.8)
Chest tightness	7 (38.9)
Tachycardia	6 (33.3)
Flushing	5 (27.8)
Throat tightness	5 (27.8)
Nausea/vomiting	4 (22.2)
Hypotension	4 (22.2)
Angioedema	4 (22.2)
Dyspnea	4 (22.2)
Delayed reaction	1 (5.6)
Median carboplatin study cycle at time of initial HSR	2 (1–5)
Median cumulative carboplatin cycle at time of initial HSR	11.5 (3–22)
Outcome
Successfully continuing on study	6 (33.3)
Off carboplatin because of HSR	5 (27.8)
Off study for progression of disease	5 (27.8)
Off study for other reasons:	2 (11.1)
Elective withdrawal	1 (5.6)
Intolerable adverse effects	1 (5.6)

Abbreviation: HSR=hypersensitivity reaction.