Table 1. Patients' characteristics.
| Characteristics | n=47 | |
|---|---|---|
| Age (median (range)) |
59 years |
(21–79) |
|
Histology | ||
| Translocation-related sarcoma |
14 |
30% |
| Myxoid liposarcoma | 4 | 9% |
| Synovial sarcoma | 6 | 13% |
| Endometrial stromal sarcoma | 3 | 6% |
| Alveolar soft part sarcoma |
1 |
2% |
| Non-translocation-related sarcoma |
33 |
70% |
| Well-differentiated liposarcoma | 4 | 9% |
| De-differentiated liposarcoma | 5 | 11% |
| Pleomorphic liposarcoma | 2 | 4% |
| Leiomyosarcoma | 10 | 21% |
| MPNST | 6 | 13% |
| Sarcoma NOS | 3 | 6% |
| Othersa |
3 |
6% |
| Metastatic disease |
43 |
92% |
|
Site of metastasis | ||
| Lung | 24 | 51% |
| Liver | 14 | 30% |
| Bone | 7 | 15% |
| Number of previous lines of chemotherapy (median (range)) |
2 |
(1–7) |
| Documented disease progression before study entry |
46 |
98% |
|
ECOG performance status | ||
| 0 | 25 | 53% |
| 1 | 12 | 26% |
| 2 | 4 | 9% |
| Unknown | 6 | 13% |
Abbreviations: ECOG=Eastern Cooperative Oncology Group; MPNST=malignant peripheral nerve sheath tumour; sarcoma NOS=sarcoma subtype not otherwise specified.
a
Other histologies were angiosarcoma (n=1), solitary fibrous tumour (n=1) and pleiomorphic rhabdomyosarcoma (n=1).