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. 2013 Aug 7;2013:157456. doi: 10.1155/2013/157456

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Copyright © 2013 Suzy M. Salama et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Immunohistochemistry staining of (a) Bax and (b) Bcl-2 of representative livers sampled from rats in different experimental groups. Less apoptosis indicated by (ia) few Bax-positive hepatocytes (white arrow) and (ib) more Bcl-2-positive hepatocytes (black arrow) in liver tissues from a cirrhosis rat group. (iia) High numbers of Bax-positive hepatocytes (White arrow) and (iib) very less Bcl-2-positive hepatocytes (black arrow) in the liver from a hepatoprotected rat treated with Silymarin. Moderate apoptosis as indicated by (iiia) moderate Bax staining (white arrow) and (iiib) moderate Bcl-2 staining (black arrow) indicating moderate apoptosis in the liver from the rats treated with low dose BR extract. (iva) High numbers of Bax-positive cells (white arrow) with severe apoptosis and (ivb) very less Bcl-2-positive hepatocytes (black arrow) were observed in the liver of the rats treated with high dose BR extract (original magnification ×40).