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A general depiction of amyloidogenic processing. Amyloid precursor protein (APP) is cleaved by β-secretase followed by γ-secretase within the bilayer to produce a fragment of amyloid-beta peptide (Aβ), sAPPβ, and AICD. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
