FIG. 6.

A pictorial representation of Aβ oligomerization and insertion into the bilayer. When inserted into the bilayer, Aβ forms an α-helix that allows the peptide backbone carbonyl of Ile-31 to come within Van der Waals distance of the sulfur atom on Met-35, as explained by the i+4 rule of α-helicies. This interaction allows for the formation of a sulfuranyl radical that leads to a catalytic lipid peroxidation process. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars