Table 6.
Clinical Correlates of Network Breakdown
| Scores | Whole brain | Left hemisphere | Right hemisphere |
|---|---|---|---|
| MMSE | 1 connection: 63 and 37 (critical FDR p=8.50E-05) | 15 connections: 3 and 3, 7 and 7, 8 and 7, 9 and 7, 9 and 9, 15 and 7, 15 and 9, 24 and 3, 27 and 3, 27 and 27, 29 and 7, 29 and 8, 30 and 7, 31 and 8, 35 and 7 (critical FDR p=0.004) | 10 connections: 11 and 1, 24 and 22, 31 and 22, 31 and 24, 31 and 25, 31 and 31, 35 and 17, 35 and 31, 35 and 35 (critical FDR p=0.002) |
| ADAS-11 | 11 connections: 15 and 13, 25 and 15, 28 and 20, 45 and 42, 46 and 40, 51 and 48, 51 and 51, 60 and 23, 63 and 37, 64 and 25, 65 and 54 (critical FDR p=0.002) | 13 connections: 7 and 7, 9 and 7, 9 and 9, 15 and 7, 23 and 8, 25 and 11, 25 and 23, 27 and 27, 29 and 18, 30 and 7, 30 and 9, 31 and 8, 35 and 7 (critical FDR p=0.004) | 16 connections: 8 and 8, 9 and 1, 11 and 1, 22 and 18, 24 and 22, 31 and 17, 31 and 18, 31 and 22, 31 and 24, 31 and 25, 31 and 31, 35 and 3, 35 and 17, 35 and 24, 35 and 31, 35 and 35 (critical FDR p=0.004) |
| ADAS-13 | 10 connections: 15 and 13, 25 and 15, 28 and 20, 45 and 42, 46 and 40, 51 and 48, 51 and 51, 63 and 37, 64 and 25, 65 and 54 (critical FDR p=0.002) | 13 connections: 7 and 7, 9 and 7, 9 and 9, 15 and 7, 23 and 8, 25 and 11, 25 and 23, 27 and 27, 28 and 18, 29 and 8, 30 and 7, 30 and 9, 31 and 8 (critical FDR p=0.004) | 7 connections: 8 and 8, 11 and 1, 31 and 18, 31 and 22, 35 and 17, 35 and 24, 35 and 35 (critical FDR p=0.002) |
| CDR-Glob | 28 connections: 14 and 12, 18 and 17, 20 and 12, 20 and 18, 20 and 20, 24 and 10, 25 and 15, 26 and 2, 27 and 14, 27 and 20, 27 and 24, 28 and 20, 30 and 11, 35 and 20, 43 and 10, 48 and 10, 48 and 25, 58 and 25, 60 and 13, 61 and 12, 61 and 26, 61 and 27, 61 and 28, 61 and 47, 61 and 61, 62 and 61, 63 and 37, 64 and 25 (critical FDR p=0.007) | 23 connections: 7 and 7, 8 and 7, 8 and 8, 21 and 7, 23 and 8, 24 and 3, 24 and 10, 25 and 7, 25 and 8, 25 and 11, 25 and 13, 25 and 15, 25 and 17, 25 and 23, 25 and 24, 25 and 25, 28 and 3, 28 and 25, 28 and 28, 29 and 8, 29 and 25, 29 and 28, 30 and 7 (critical FDR p=0.007) | 8 connections: 8 and 8, 29 and 8, 29 and 23, 29 and 29, 31 and 31, 35 and 24, 35 and 31, 35 and 35 (critical FDR p=0.002) |
| CDR-SOB | 10 connections: 23 and 8, 24 and 10, 28 and 20, 30 and 11, 31 and 3, 37 and 37, 48 and 10, 48 and 25, 63 and 37, 64 and 25 (critical FDR p=0.002) | 6 connections: 3 and 3, 7 and 7, 8 and 7, 15 and 7, 25 and 25, 28 and 3 (critical FDR p=0.001) | 7 connections: 31 and 17, 31 and 25, 31 and 31, 35 and 17, 35 and 24, 35 and 31, 35 and 35 (critical FDR p=0.002) |
Here we show various differences in brain networks that are associated with standard measures of clinical decline. Random effects regression tests were performed for clinical scores on the MMSE, CDR-Glob, CDR-sob, ADAS-11 and ADAS-13 in the whole brain, left, and right hemispheres separately for the k-cores of all subjects (controls, eMCI, MCI and AD) in connections present in 80% of subjects. We used site as a random regression variable, and controlled for age and sex. All the nodes that showed significant differences are listed. Significant connections that are common across all clinical scores are shown in bold and the critical FDR p-value for correcting over all valid connections is shown.
MMSE, Mini Mental State Examination; ADAS-11, 11 item Alzheimer's Disease Assessment Scale-Cognitive Subscale; ADAS-13, 13-item Alzheimer's Disease Assessment Scale-Cognitive Subscale; CDR-Glob, Clinical Dementia Rating Sum of Boxes; CDR-Glob, Clinical Dementia Rating Global Score; FDR, false discovery rate.