Table 2.
Mitochondrial Markers in Matched Cases and Controls
| |
Median (25th, 75th) |
|
|
|
|---|---|---|---|---|
| Mitochondrial markers | Controls | Cases | Mean difference (95% CL) | p-value |
| MtDNA copies/cell | ||||
| With outlier | 199 (80, 421) | 158 (96, 443) | −39.9 (−87.81, 8.0) | 0.098 |
| Without outlier | 182 (80, 347) | 153 (96, 229) | −40.5 (−79.8, −1.3) | 0.044 |
| C1 enzyme activity (×1,000 optical density units) | 86.10 (13.70, 17.4) | 94.80 (11.4, 172) | 10.4 (−15.16, 35.9) | 0.41 |
| C4 enzyme activity (×1,000 optical density units) | 65.40 (18.00, 134.4) | 72.90 (7.6, 128.2) | 1.3 (−17.8, 20.4) | 0.89 |
MtDNA, mitochondrial DNA; CL, confidence limit; C1, Complex I NADH dehydrogenase; C4, Complex IV cytochrome c oxidase; outlier value was >3 IQR in cases and >1.5 IQR in controls.