Table 1. Effect of LiaR deletion in murine models of GBS sepsis and pneumonia.

	Sepsis model*		Pneumonia model†
Strain	LD50 trial 1	LD50 trial 2	Survival no. (%)	Lungs (c.f.u.)	Spleen (c.f.u.)
A909	1.0×104	7.5×104	4/19 (19)	2.3×108	5.9×107
A909ΔliaR	6.5×106	9.5×106	14/14 (100)	9.9×102	2.0×102
A909ΔliaR+pLiaR	ND	1.5×106	ND	ND	ND

^*Sepsis model LD₅₀ expressed as bacterial c.f.u. (colony-forming units). LD₅₀ calculated by survival 96 h post-intraperitoneal injection, using the method of Reed & Muench (1938). The difference in mean LD₅₀ between A909 and A909ΔliaR is statistically significant (P = 0.0338 by t-test).

^†Survival was calculated at 48 h post-nasal injection. The difference in survival between A909 and A909ΔliaR is statistically significant with P<0.0001 by Fisher’s exact test. Bacterial c.f.u. recovered from the lungs and spleens in the pneumonia model were obtained from three different mice (A909) and two different mice (A909ΔliaR).