Table 1.
GWAS signals from loci previously reported to be associated with psoriasis.
| Chr | SNP | Positiona | Gene/ Locus |
P value | OR (95% CI) | Reference |
|---|---|---|---|---|---|---|
| 1p31 | rs11209026 | 67478546 | IL23R | 7.13×10−07 | 1.49 (1.27-1.74) | [5] |
| 1q21 | rs4112788 | 150817900 | LCE3D | 3.32×10−10 | 1.29 (1.19-1.40) | [9] |
| 5q31 | rs20541 | 132023863 | IL13 | 2.32×10−02 | 1.12 (1.02-1.24) | [8] |
| 5q33 | rs1024995b | 150456197 | TNIP1 | 3.92×10−05 | 1.27 (1.14-1.44) | [8] |
| 5q33 | rs3213094 | 158683347 | IL12B | 4.93×10−11 | 1.39 (1.26-1.53) | [8] |
| 6p21 | rs10484554c | 31382534 | HLA-C | 4.06×10−214 | 4.66 (4.23-5.13) | [8] |
| 6q23 | rs610604 | 138241110 | TNFAIP3 | 6.54×10−07 | 1.22 (1.13-1.32) | [8] |
| 12q13 | rs2066808 | 55024240 | IL23A | 2.49×10−07 | 1.49 (1.28-1.73) | [8] |
| 20q13 | rs2235617d | 47988384 | ZNF313 | 1.65×10−06 | 1.20 (1.11-1.30) | [4] |
SNPs reported in previous studies with robust GWAS and replication evidence. Odds ratios given for the previously reported risk allele.
a
NCBI human genome build 36 coordinates.
b
r2 = 0.48 (0.49) with previously published SNP rs177283388.
c
At the HLA locus the results are presented for our top SNP
d
r2 = 1 with previously published SNP rs4953374. All r2 calculated from 58C and where different, the r2 from HapMap CEU is in brackets.