Table 2.

Cardiovascular manifestations of different classes of chemotherapeutical drugs (modified from 3).

Chemoterapeutical drug	Cardiovascular manifestations
Anthracyclines	LVD, HF, myocarditis, arrhythmia
5-fluorourcil	Ischemia, HF, pericarditis, cardiogenic shock
Taxanes (paclitaxel), vinca alkaloids	Sinus bradicardia, ventricular tachycardia, atrioventricular block, HF, ischemia
Cyclophosphamide	HF (neurohumoral activation), mitral regurgitation
Trastuzumab	HF, LVD, arrhythmia
Tamoxifen	Thromboembolism, cholesterol metabolism anomalies
Bevacizumab	Hypertension, thromboembolism
COX-2 specific inhibitors	Thromboembolism

LVD: left ventricular dysfunction; HF: heart failure