Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Immunol. 2013 May 29;191(1):415–423. doi: 10.4049/jimmunol.1201732

Figure 1.

Figure 1

Adoptively transferred naïve CD4 T cells specific against HEL induce various levels of ocular inflammation in recipient mice expressing HEL in their lens following treatment with the tested TLR ligands. (A) Histological sections of eyes from recipient mice, 7 days post transfer of 5 million naïve CD4 cells. Shown are the retinas at the optic nerve head area (a major entry site for the activated lymphocytes). Inflammatory cells infiltrating the retina and vitreous of ligand-treated mice, but not of the controls treated with PBS. V, vitreous; R, retina; O, optic nerve head. (B) Flow cytometric analysis of cells collected from the recipient eyes, determining the proportions of CD4 cells of the donor (1G12+) and host (1G12−) cells among the total retrieved ocular cells. (C) Mean numbers of donor and host CD4 cells collected from inflamed eyes, indicating the various levels of severity of the inflammatory response.