Table 1. Factorial design of non-PEGylated nanoparticles bearing temozolomide.
| Formulation code |
Independent variable level |
Percent drug entrapment (%) | Particle size (nm) | |||
|---|---|---|---|---|---|---|
| Drug (mg) | PLGA (mg) | PVA (%) | ST (sec) | |||
| 1 |
0 |
-1 |
-1 |
-1 |
54.23 |
115.67 |
| 2 |
0 |
0 |
-1 |
-1 |
74.34 |
116.56 |
| 3 |
0 |
1 |
-1 |
-1 |
76.09 |
117.49 |
| 4 |
0 |
-1 |
0 |
-1 |
56.21 |
116.63 |
| 5 |
0 |
0 |
0 |
-1 |
77.32 |
117.61 |
| 6 |
0 |
1 |
0 |
-1 |
77.96 |
118.76 |
| 7 |
0 |
-1 |
1 |
-1 |
56.54 |
118.49 |
| 8 |
0 |
0 |
1 |
-1 |
77.43 |
119.49 |
| 9 |
0 |
1 |
1 |
-1 |
77.74 |
120.88 |
| 10 |
0 |
-1 |
-1 |
0 |
53.67 |
113.98 |
| 11 |
0 |
0 |
-1 |
0 |
73.61 |
115.49 |
| 12 |
0 |
1 |
-1 |
0 |
75.23 |
115.92 |
| 13 |
0 |
-1 |
0 |
0 |
55.61 |
114.96 |
| 14 |
0 |
0 |
0 |
0 |
76.56 |
116.37 |
| 15 |
0 |
1 |
0 |
0 |
77.21 |
116.84 |
| 16 |
0 |
-1 |
1 |
0 |
55.97 |
116.82 |
| 17 |
0 |
0 |
1 |
0 |
76.89 |
117.47 |
| 18 |
0 |
1 |
1 |
0 |
77.19 |
119.35 |
| 19 |
0 |
-1 |
-1 |
1 |
52.89 |
111.91 |
| 20 |
0 |
0 |
-1 |
1 |
72.77 |
113.67 |
| 21 |
0 |
1 |
-1 |
1 |
74.41 |
113.62 |
| 22 |
0 |
-1 |
0 |
1 |
54.32 |
112.83 |
| 23 |
0 |
0 |
0 |
1 |
75.41 |
113.85 |
| 24 |
0 |
1 |
0 |
1 |
76.1 |
114.98 |
| 25 |
0 |
-1 |
1 |
1 |
54.32 |
114.89 |
| 26 |
0 |
0 |
1 |
1 |
75.67 |
115.58 |
| 27 |
0 |
1 |
1 |
1 |
76.02 |
117.37 |
| 28 | 0 | 0 | 0 | 0 | 76.02 | 112.93 |