Table 2. Factorial design for PEGylated nanoparticles bearing temozolomide.
| Formulation code | Independent variable level |
Percent drug entrapment (%) (PDE) |
Particle size (PS) (nm) |
|||
|---|---|---|---|---|---|---|
| Drug (mg) | PLGA (mg) | PVA (%) | ST (sec) | |||
| 1 |
0 |
-1 |
-1 |
-1 |
51.85 |
119.14 |
| 2 |
0 |
0 |
-1 |
-1 |
71.85 |
120.41 |
| 3 |
0 |
1 |
-1 |
-1 |
74.03 |
121.78 |
| 4 |
0 |
-1 |
0 |
-1 |
54.32 |
119.45 |
| 5 |
0 |
0 |
0 |
-1 |
75.01 |
121.2 |
| 6 |
0 |
1 |
0 |
-1 |
75.72 |
122.01 |
| 7 |
0 |
-1 |
1 |
-1 |
54.71 |
120.33 |
| 8 |
0 |
0 |
1 |
-1 |
75.91 |
122.31 |
| 9 |
0 |
1 |
1 |
-1 |
75.34 |
123.76 |
| 10 |
0 |
-1 |
-1 |
0 |
51.45 |
117.81 |
| 11 |
0 |
0 |
-1 |
0 |
71.25 |
119.32 |
| 12 |
0 |
1 |
-1 |
0 |
73.23 |
121.43 |
| 13 |
0 |
-1 |
0 |
0 |
53.43 |
118.79 |
| 14 |
0 |
0 |
0 |
0 |
73.83 |
120.32 |
| 15 |
0 |
1 |
0 |
0 |
75.12 |
121.02 |
| 16 |
0 |
-1 |
1 |
0 |
53.88 |
119.32 |
| 17 |
0 |
0 |
1 |
0 |
74.86 |
121.2 |
| 18 |
0 |
1 |
1 |
0 |
74.33 |
122.45 |
| 19 |
0 |
-1 |
-1 |
1 |
49.62 |
116.31 |
| 20 |
0 |
0 |
-1 |
1 |
70.37 |
118.32 |
| 21 |
0 |
1 |
-1 |
1 |
71.93 |
120.67 |
| 22 |
0 |
-1 |
0 |
1 |
52.85 |
113.84 |
| 23 |
0 |
0 |
0 |
1 |
73.12 |
119.21 |
| 24 |
0 |
1 |
0 |
1 |
73.71 |
119.82 |
| 25 |
0 |
-1 |
1 |
1 |
52.81 |
118.33 |
| 26 |
0 |
0 |
1 |
1 |
72.96 |
120.82 |
| 27 |
0 |
1 |
1 |
1 |
72.88 |
121.35 |
| 28 | 0 | 0 | 0 | 0 | 75.12 | 117.23 |