Table II.
Maternal, paternal and neonatal ACE A11860G genotype distribution in uncomplicated pregnancies and SGA pregnancies, stratified by cohorts.
Combined SCOPE |
Adelaide SCOPE |
Auckland SCOPE |
|||||||
---|---|---|---|---|---|---|---|---|---|
Uncomplicated (%) | SGA (%) | OR (95% CI) | Uncomplicated (%) | SGA (%) | OR (95% CI) | Uncomplicated (%) | SGA (%) | OR (95% CI) | |
Maternal ACE A11860G | n = 1064 | n = 203 | n = 382 | n = 101 | n = 682 | n = 102 | |||
AA/AG | 778 (73.1) | 131 (64.5) | Ref | 295 (77.2) | 63 (62.4) | Ref | 483 (70.8) | 68 (66.7) | Ref |
GG | 286 (26.9) | 72 (35.5) | 1.5(1.1–2.1) | 87 (22.8) | 38 (37.6) | 2.0 (1.3–3.3) | 199 (29.2) | 34 (33.3) | 1.2 (0.8–1.9) |
Paternal ACE A11860G | n = 921 | n = 179 | n = 337 | n = 97 | n = 584 | n = 82 | |||
AA/AG | 654 (71.0) | 128 (71.5) | Ref | 237 (70.3) | 72 (74.2) | Ref | 417 (71.4) | 56 (68.3) | Ref |
GG | 267 (29.0) | 51 (28.5) | 1.0(0.7–1.4) | 100 (29.7) | 25 (25.8) | 0.8 (0.5–1.4) | 167 (28.6) | 26(31.7) | 1.2 (0.7–1.9) |
Neonatal ACE A11860G | n = 888 | n = 145 | n = 308 | n = 71 | n = 580 | n = 74 | |||
AA/AG | 625 (70.4) | 100 (69.0) | Ref | 224 (72.7) | 48 (67.6) | Ref | 401 (69.1) | 52 (70.3) | Ref |
GG | 263 (29.6) | 45 (31.0) | 1.1(0.7–1.6) | 84 (27.3) | 23 (32.4) | 1.3 (0.7–2.2) | 179 (30.9) | 22 (29.7) | 1.0 (0.6–1.6) |
Data are presented as n (%). Ref, reference. Italic values indicate significant difference.