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mPer2Luc Bioluminescence Patterns of Individual Fibroblasts Ten single-cell fibroblast rhythms representative of each genotype are presented for (A) WT, (B) Cry1−/−, (C) Cry2−/−, and (D) Per1−/−. Imaging began immediately following a change to fresh EM (day 0). These results show that both Cry1 and Per1 are required for sustained rhythmicity in the fibroblasts.
