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mPer2Luc Bioluminescence Patterns of Individual SCN Neurons Ten single SCN neuron rhythms representative of each genotype are presented for (A) WT, (B) Cry1−/−, (C) Cry2−/−, and (D) Per1−/−. Imaging began immediately following a change to fresh EM (day 0). These results show that both Cry1 and Per1 are required for sustained rhythmicity in SCN neurons. See Movies S1 and S2 for dynamic views of Cry2−/− and Cry1−/− neurons, respectively.
