Table 2.

Summary of studies of serotonin-2A receptors in postmortem brain tissue in suicide and depression

Radioligand	Type of binding study	Brain region	Result	Reference
[3H]spiperone	Homogenate	PFC 8, 9	↑ Bmax	Stanley and Mann 1983 (164)
[3H]ketanserin	Homogenate	PFC 8, 9	No change	Owen et al. 1983 (165)
[3H]ketanserin	Homogenate	PFC 10	No change	Crow et al. 1984 (166)
[3H]ketanserin	Homogenate	Frontal cortex	No change	Owen et al. 1986 (167)
[3H]spiperone	Homogenate	PFC 8, 9	↑ Bmax	Mann et al. 1986 (82)
[3H]ketanserin	Homogenate	PFC 10	No change	McKeith et al. 1987 (168)
[3H]ketanserin	Homogenate	PFC 10, hippocampus	No change in PFC, ↓ in hippocampus	Cheetaham et al. 1988 (169)
[3H]spiperone	Homogenate	PFC 8, 9	↑ Bmax only in violent suicides	Arora and Meltzer 1989 (170)
[125I]LSD	Homogenate and sections	PFC 9	↑ Bmax and ↑ in sections	Arango et al. 1990 (83)
[3H]ketanserin	Homogenate and sections	PFC, hippocampus	↓ Bmax and ↓ in sections in PFC only	Gross-Isseroff et al. 1990 (85)
[3H]ketanserin	Sections	PFC 9	↑ mid-layers	Yates et al. 1990 (171)
[3H]ketanserin	Homogenate	PFC 10	↑ Bmax	Laruelle et al. 1993 (172)
[3H]ketanserin	Homogenate	PFC 9, amygdala	↑ Bmax	Hrdina et al. 1993 (173)
[125I]LSD	Sections	Temporal and entorhinal cortex, hippocampus	No change	Joyce et al. 1993 (68)
[3H]ketanserin	Homogenate	PFC 9, 10, 11	No change in violent or nonviolent	Arranz et al. 1994 (174)
[3H]spiperone	Homogenate	PFC 10, hippocampus	No change	Lowther et al. 1994 (175)
[3H]ketanserin	Sections	PFC 10, hippocampus	No change	Stockmeier et al. 1997 (176)
[3H]ketanserin	Homogenate	PFC 8, 9	↑ Bmax	Turecki et al. 1999 (177)
[3H]ketanserin	Homogenate	PFC 9, 10, 11, hippocampus	No change in PFC, ↓ Bmax in hippocampus	Rosel et al. 2000 (178)
[3H]LSD	Homogenate	PFC 8, 9	↑ Bmax	Pandey et al. 2002 (23)

PFC = prefrontal cortex; ↑ = increase; ↓ = decrease.