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. 2013 May 10;22(18):3609–3623. doi: 10.1093/hmg/ddt212

Figure 1.

Figure 1.

The expression of GATA3 in the developing mouse inner ear. (A) Immunolabeling on transverse sections through the otic vesicle reveals that GATA3 is expressed in the entire otocyst at E9.5. (B and C) The expression of GATA3 is detected in the dorsolateral and ventromedial domains of the otocyst at E10.5 and E11.5. (D) At E12.5, GATA3 is widely expressed in the ventral cochlear duct and partially in the CVG. (E–H) From E13.5, GATA3 is strongly expressed in the SG and the cochlear duct. (I–L) Co-immunolabeling shows that GATA3 expression partially overlaps with that of NEUROD in the CVG at E9.5 to E12.5. (M–P) GATA3 is similarly expressed in a subset of ISL1+ CVG cells at E10.5–E12.5. (Q–T) Co-immunolabeling of GATA3 and TUJ1 shows that GATA3 is continuously expressed in SG from E12.5. OV, otic vesicle; CD, cochlear duct; CVG, cochlear-vestibular ganglion; SG, spiral ganglion; D, dorsal; M, medial; V, ventral; A, anterior; L, lateral. Scale bar, 50 µm.