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. 2013 May 10;22(18):3609–3623. doi: 10.1093/hmg/ddt212

Figure 8.

Figure 8.

Gata3 is required for the survival of SGNs. (A–J) Quantification of cell proliferation in the CVG shows no significant change of cell proliferating in Gata3-null mice (n = 3 for wild-types and n = 4 for Gata3-nulls). Data are shown as the mean ± SEM. NS, not significant. (H–I) The number of CASP3+ apoptotic cells is greatly increased in the spiral ganglion of Gata3-null mice. (J–M) Further analysis of cell death at E13.5 and E14.5 shows dramatically elevated cell death of SGNs in Gata3-null mice. (N) The number of ISL1+ CVG neurons is significantly decreased in Gata3-null mice at E12.5 (*P < 0.001, two-tailed Student's test, n = 4 for mutants and n = 5 for controls). (O) Quantification of cell apoptosis rate (CASP3+/ISL1+) in spiral ganglion at E12.5 reveals greatly increased cell death in Gata3-null mice (*P < 0.05, two-tailed Student's test, n = 3). CD, cochlear duct; SG, spiral ganglion neurons. Scale bars, 50 µm.