Table 2.

Correlations of adrenal Chga protein with hypertensive disease biochemical phenotypes in the RI strains

Hypertensive disease trait correlated with adrenal Chga protein in the HXB/BXH RI strains	Correlation coefficient (r)	Correlation P-value	Number of RI strains
Catecholamines
Adrenal epinephrine (μg/mg protein)	0.492	0.00512*	30
Adrenal norepinephrine (μg/mg protein)	0.481	0.00645*	30
Adrenal dopamine (μg/mg protein)	0.427	0.01786*	30
Catecholamine biosynthetic enzymes
Adrenal Pnmt (nmol/h/mg protein)	0.628	0.00013*	30
Adrenal Dbh (nmol/h/mg protein)	0.510	0.00344*	30
Chromogranins
Adrenal Chgb (fragments/ml)	0.546	0.00146*	30
Steroid hormones
Adrenal corticosterone (pg/mg protein)	0.636	0.00009*	30

Analysis of the HXB/BXH RI strains identified significant parametric (Pearson) correlations (*P < 0.05) of adrenal Chga protein with multiple adrenal biochemical regulators of blood pressure.

Pnmt (phenylethanolamine N-methyltransferase), Dbh (dopamine beta-hydroxylase), Chgb (chromogranin B).