Table 2.
Hypertensive disease trait correlated with adrenal Chga protein in the HXB/BXH RI strains | Correlation coefficient (r) | Correlation P-value | Number of RI strains |
---|---|---|---|
Catecholamines | |||
Adrenal epinephrine (μg/mg protein) | 0.492 | 0.00512* | 30 |
Adrenal norepinephrine (μg/mg protein) | 0.481 | 0.00645* | 30 |
Adrenal dopamine (μg/mg protein) | 0.427 | 0.01786* | 30 |
Catecholamine biosynthetic enzymes | |||
Adrenal Pnmt (nmol/h/mg protein) | 0.628 | 0.00013* | 30 |
Adrenal Dbh (nmol/h/mg protein) | 0.510 | 0.00344* | 30 |
Chromogranins | |||
Adrenal Chgb (fragments/ml) | 0.546 | 0.00146* | 30 |
Steroid hormones | |||
Adrenal corticosterone (pg/mg protein) | 0.636 | 0.00009* | 30 |
Analysis of the HXB/BXH RI strains identified significant parametric (Pearson) correlations (*P < 0.05) of adrenal Chga protein with multiple adrenal biochemical regulators of blood pressure.
Pnmt (phenylethanolamine N-methyltransferase), Dbh (dopamine beta-hydroxylase), Chgb (chromogranin B).