Table 5.
Chemistry panel marker | SHR treated with control (mean ± SEM) | SHR treated with antagomir (mean ± SEM) | P-value |
---|---|---|---|
General metabolism | |||
Glucose (mg/dl) | 189 ± 5 | 196 ± 3 | 0.23 |
Kidney function | |||
BUN (mg/dl) | 20 ± 1 | 20 ± 1 | 0.70 |
Creatinine (mg/dl) | 0.2 ± 0.01 | 0.2 ± 0.02 | 0.34 |
Electrolytes | |||
Sodium (mEq/l) | 162 ± 1 | 164 ± 1 | 0.33 |
Phosphorus (mg/dl) | 9.9 ± 0.2 | 9.5 ± 0.2 | 0.13 |
Liver function | |||
Alkaline phosphatase (U/l) | 29 ± 10 | 21 ± 6 | 0.49 |
Albumin (g/dl) | 4.7 ± 0.1 | 4.7 ± 0.1 | 0.89 |
SGPT (ALT) (U/l) | 68 ± 5 | 55 ± 2 | 0.02* |
Total protein (g/dl) | 5.8 ± 0.1 | 5.8 ± 0.1 | 0.46 |
Globulin (g/dl) | 1.1 ± 0.1 | 1.1 ± 0.1 | 0.75 |
Total bilirubin (mg/dl) | 0.2 ± 0.01 | 0.2 ± 0.02 | 0.34 |
Pancreas function | |||
Amylase (U/l) | 846 ± 17 | 729 ± 23 | 0.0008* |
A standard chemistry panel was performed on plasma from SHR treated with miR-22 antagomir or negative control. Data were analyzed with Student's t-test. Statistically significant differences (P < 0.05) are indicated with *.
BUN, blood urea nitrogen; SGPT, serum glutamic pyruvic transaminase.