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Effect of compound V in wild-type mice. Two groups of six wild-type C57BL/6 mice were orally treated for 12 days with 0.25 mg/kg/day or 5 mg/kg/day of compound V. The control animals (five mice) were treated with 10% DMSO in a 9% glucose solution, i.e. the vehicle for compound V administration. After treatment, whole liver and whole brain extracts were prepared and ATR protein levels detected by immunoblotting (represented as the mean ± SD for each group). *P < 0.05.
