Humanized mice for immune system investigation: progress, promise and challenges

. Author manuscript; available in PMC: 2013 Aug 22.

Published in final edited form as: Nat Rev Immunol. 2012 Oct 12;12(11):786–798. doi: 10.1038/nri3311

Platform Stocks of Immunodeficient Mice	Common Abbreviation	Characteristics
NOD.Cg-Prkdc^scidIl2rg^tm1Wjl	NSG	The Il2rg targeted mutation is a complete null, is not expressed and will not bind cytokines
NOD.cg-Prkdc^scidIl2rg^tm1Sug	NOG	The Il2rg chain lacks the intracytoplasmic domain. It Is expressed and will bind cytokines but will not signal
C;129S4- Rag2^tm1.1Flv	BRG	On a mixed BALB/c x 129 Rag2^null strain. Il2rg is complete null, is not expressed and will not bind cytokines
Platform Genes to Create Immunodeficient Mice
protein kinase, DNA activated, catalytic polypeptide	Prkdc^scid (often abbreviated as scid)	Double strand DNA repair defect that prevents TCR and BCR recombination
recombination activating gene 1 recombination activating gene 2	Rag1^−/−Rag2^−/−	T and B cell receptor recombination defects T and B cell receptor recombination defects