TABLE II.
Drug resistance profiles of isolates from 213 patients with pulmonary tuberculosis (TB) confirmed by isolation of Mycobacterium tuberculosis and who underwent drug susceptibility testing, Santos, Brazil, 2000–2004
| New cases (n = 86) | Prior TB treatment (n = 127) | Total (n = 213) | |
|---|---|---|---|
| Characteristics | n (%) | n (%) | n (%) |
| Sensitive to all drugs | 64 (74.4) | 93 (73.2) | 157(73.7) |
| Resistant to any drug | 22 (25.6) | 34 (26.7) | 56 (26.3) |
| IHN | 19 (22.1) | 31 (24.4) | 50 (23.5) |
| RMP | 11 (12.8) | 24 (18.9) | 35 (16.4) |
| PZA | 6 (7) | 14 (11) | 20 (9.4) |
| SM | 5 (5.8) | 6 (4.7) | 11 (5.2) |
| EM | 3 (3.5) | 7 (5.5) | 10 (4.7) |
| Resistant to one drug | 10 (11.6) | 10 (7.8) | 20 (9.4) |
| IHN | 7 (8.1) | 7 (5.5) | 14 (6.6) |
| RMP | 1 (1.2) | 2 (1.6) | 3 (1.4) |
| SM | 1 (1.2) | - | 1 (0.5) |
| EM | 1 (1.2) | 1 (0.8) | 2 (0.9) |
| MDR | 10 (11.6) | 22 (17.3) | 32 (15) |
| INH + RMP | 4 (4.7) | 6 (4.7) | 10 (4.7) |
| INH + RMP + PZA | 2 (2.3) | 8 (6.3) | 10 (4.7) |
| INH + RMP + PZA + SM | 3 (3.5) | 1 (0.8) | 4 (1.9) |
| INH + RMP + PZA + EM | 1 (1.2) | 3 (2.4) | 4 (1.9) |
| INH + RMP + PZA + SM + EM | - | 1 (0.8) | 1 (0.5) |
| INH + RMP + SM | - | 1 (0.8) | 1 (0.5) |
| INH + RMP + SM + EM | - | 2 (1.6) | 2 (0.9) |
| Other drug resistance profiles | 2 (2.3) | 2 (1.6) | 4 (1.9) |
| INH + PZA | - | 1 (0.8) | 1 (0.5) |
| INH + EM + SM | - | 1 (0.8) | 1 (0.5) |
| INH + SM | 1 (1.2) | - | 1 (0.5) |
| INH + EM | 1 (1.2) | - | 1 (0.5) |
EM: ethambutol; INH: isoniazide; MDR: multidrug resistant; PZA: pyrazinamide; RMP: rifampicin; SM: streptomycin; TB: tuberculosis.