Table 2.

Comparision of responses in parabiotic partners of obese rats and mice.

Model of obesity	Representative leptin values for obese animal** (ng/ml)	Body fat	Lean body mass	Food intake/gut content*
VMH lesioned rat	301	Decreased	Decreased	Decreased 10–20%
LH stimulated rat		Decreased	Decreased	Decreased 70%
Intubated overfed rat		Decreased	Not measured	Decreased 15–30%
Tubefed overfed rat	242	Decreased	Unchanged	Unchanged
Male Zucker rat	503	Decreased	Decreased	Unchanged
Female Zucker rat	423	Decreased	Decreased	Decreased 21%
ob/ob partner of db/db mouse	254	Decreased	Unchanged	Decreased 75%
Wild type partner of db/db mouse	254	Decreased	Decreased	Unchanged
Leptin injected ob/ob mouse		Decreased	Unchanged	Decreased 75%

The change in food intake is the only parameter that is quantified because changes in body composition are influenced by the duration of the study.

^*Gut content shows a high correlation with the amount of food consumed during the previous 24 hours (Harris, Zhou, Weigle, & Kuijper, 1997).

^**Leptin values are taken from published data on single animals of the same genotype as the obese parabiont.

¹(Dube, Xu, Kalra, Sninsky, & Kalra, 1999),

²Harris (unpublished data),

³(Bogacka, et al., 2004),

⁴(Harris, Mitchell, Yan, Simpson, & Redmann, 2001).