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. Author manuscript; available in PMC: 2013 Aug 22.
Published in final edited form as: Pediatr Res. 2009 Sep;66(3):289–294. doi: 10.1203/PDR.0b013e3181b1bc89

Figure 5.

Figure 5

K+ current from control pulmonary artery VSMC in the presence of xanthine alone (A), xanthine+xanthine oxidase to generate superoxide (B) and xanthine+xanthine oxidase+4-AP (C). Xanthine alone (A) did not alter the K+ current. Addition of xanthine+xanthine oxidase resulted in suppression of K+ current (B). Further addition of 4-AP fails to alter K+ current in the presence of xanthine+xanthine oxidase (C), suggesting inhibition of Kv current by superoxide. Summary data in panel D show that xanthine+xanthine oxidase (-●-) attenuates the K+ current density compared to xanthine alone (-○-) and addition of 4-AP to xanthine+xanthine oxidase (-△-) does not attenuate the K+ current further.