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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Cell Physiol. 2013 Jul;228(7):1601–1609. doi: 10.1002/jcp.24323

Fig. 2. β1 integrins promote resistance to fractionated doses of radiation in vivo.

Fig. 2

A: Kaplan-Meier survival analysis. β1pc−/−/TRAMP cohort (n=11) shows a statistically significant increase in lifespan as compared to the β1wt/TRAMP cohort (n=10, P=0.0035) upon irradiation. B: PC3 cell xenograft-bearing nude mice were analyzed. Once the tumors reached 100 mm3 (day 0), AIIB2 Ab or non-specific rtIgG was injected intraperitoneally (5 mg/Kg) on day 0 and day 14. Twenty-four h after first injection, tumors were irradiated (0 or 10 Gy) and tumor volume was measured up to 20 days. Data are the mean ± SEM of 6 animals per group. The differences in tumor volume during the time frame of 10 to 20 days after injection are statistically significant at each time point as indicated in the figure (P<0.001). The graph shows kinetics of tumor growth (upper panel). The lower panel shows a schematic representation of the experiment. Statistical analysis was conducted using the Student's t-test.