Table 1. The ten most strongly associated SNPs in the unconditional GWAS on AAT serum level in SAPALDIA (N = 1392).

SNP	Chromosome	Position	Gene	Location	Determination	MAF	Imp-r2	Allele Effect	P
rs2736887	14	93882733		intergenic	imputed	0.185	0.950	0.071	2.48E-13
rs926144	14	93883155		intergenic	imputed	0.186	0.950	0.071	2.72E-13
rs7151526	14	93933389	SERPINA1	5′UTR	imputed	0.065	0.769	0.116	6.78E-13
rs4905179	14	93865245	SERPINA6	5′UTR	genotyped	0.180	1.000	0.068	1.20E-12
rs11621961	14	93839229	SERPINA6	3′UTR	genotyped	0.355	0.945	0.052	1.37E-11
rs17751837	14	93937997	SERPINA1	5′UTR	genotyped	0.097	0.995	0.063	8.56E-08
rs1028580	14	93919635	SERPINA1	intron	imputed	0.154	0.979	0.051	4.87E-07
rs8010121	14	93920367	SERPINA1	intron	genotyped	0.155	0.999	0.049	6.64E-07
rs3748312	14	93924017	SERPINA1	intron	imputed	0.148	0.846	0.053	9.84E-07
rs17752593	14	94007781	SERPINA9	intron	genotyped	0.129	0.997	0.053	1.59E-06

Abbreviations: AAT, alpha1-antitrypsin; GWAS, genome-wide association study; MAF, minor allele frequency; SNP, single nucleotide polymorphism.

Imp-r² is an indicator for imputation quality. SNPs with MAF<0.05 or imp-r²<0.5 were excluded.

Chromosomal position is based on reference panel, NCBI build 36.3. Allele effects are shown in absolute numbers.