Table 5. Minor allele effects on FEV1 of low-frequent and common SNPs in the SERPINA gene cluster in ever-smokers undergoing lung resection.

SNP	MAF	Imp-r2	Allele Effect (L)	P	MAF	Imp-r2	Allele Effect (L)	P
	Groningen (N = 133)				University of British Columbia, UBC (N = 264)
rs17580 (PI S)	0.055	0.72	0.42	0.10	0.079	0.76	−0.15	0.29
rs28929474 (PI Z)	0.123	0.98	−0.68	<0.001	0.032	0.98	−0.81	<0.0001
rs4905179	0.299	1.00	−0.22	0.04	0.249	naa	−0.23	0.002
rs4905179, adjusted for PI S and Z			−0.07	0.65			−0.08	0.36
rs3748312	0.233	0.95	−0.34	0.008	0.148	0.94	−0.16	0.07
rs3748312, adjusted for PI S and Z			0.16	0.37			0.09	0.35

Abbreviations: FEV1, forced expiratory volume in one second; MAF, minor allele frequency; SNP, single nucleotide polymorphism.

Imp-r² is an indicator for imputation quality. The analyses were adjusted for age, sex and height.

^aRs4905179 was genotyped in UBC.