|
Informational
|
EcF11_3256
|
bipA, typA
|
<0.0001 |
−8.12 |
blood,PC |
Unclassified |
Cold stress response [53]
|
E. coli K12 lab strain/in vitro
|
|
|
|
|
|
|
|
Co-ordination of pathogenicity island gene expression [30]
|
EPEC/in vitro
|
|
|
|
|
|
|
|
BipA binds ribosome under stress conditions [35]
|
Salmonella enterica/in vitro
|
|
|
|
|
|
|
|
Stress adaptation and symbiosis [36]
|
Sinorhizobium meliloti/in vivo plant model |
|
EcF11_5238
|
hdeD
|
0.0128 |
−4.80 |
blood,PC |
Hypothetical |
Acid stress regulon [54]
|
E. coli K12 lab strain/in vitro
|
|
EcF11_1255
|
lrhA
|
0.0001 |
−3.35 |
blood,PC |
Hypothetical |
Regulation of virulence genes [31]
|
EHEC/in vitro
|
|
|
|
|
|
|
|
Regulation of motility, lipase activity, toxin expression and virulence [55]
|
Xenorhabdus nematophila/in vivo insect model |
|
EcF11_2271
|
rfaH
|
0.0002 |
−7.29 |
blood,PC |
Informational (transcription factor) |
Global regulator of virulence [32]
|
UPEC/in vitro and in vivo mouse model |
|
EcF11_4315
|
nhaR
|
0.0121 |
−1.36 |
blood,PC |
Informational (transcription factor) |
Regulates genes that facilitate cell-cell adhesion and adhesion to host cells [56]
|
Proteus Mirabilis/in vivo mouse model |
|
EcF11_0317
|
sirB1
|
0.0268 |
−3.26 |
blood |
Hypothetical |
Regulation of the SPI type III secretion system [67]
|
Salmonella typhimurium/in vitro
|
|
EcF11_5302
|
hdfR
|
0.0019 |
−3.44 |
blood |
Hypothetical |
Regulator of the std fimbrial operon [68]
|
Salmonella enterica/in vitro
|
|
|
|
|
|
|
|
Regulates flagellar synthesis [69]
|
E. coli K12 lab strain/in vitro
|
|
Membrane architecture
|
EcF11_1390
|
kpsM
|
0.0033 |
−8.11 |
blood,PC |
Environmental interactions (transporter) |
Capsular polysaccharide exporter [70]
|
E. coli K1/in vitro
|
|
|
|
|
|
|
|
KpsM is predominantly encoded by strains of the E. coli B2 phylotype [71]
|
E. coli/in silico
|
|
|
|
|
|
|
|
Resistance against phagocyte-mediated killing [33]
|
ExPEC/tissue culture |
|
EcF11_1396
|
kpsS
|
0.0229 |
−3.84 |
blood,PC |
Unclassified |
Capsular polysaccharide exporter [72]
|
E. coli K5/in vitro
|
|
EcF11_1397
|
kpsC
|
0.0035 |
−2.57 |
blood |
Unclassified |
Capsular polysaccharide exporter [73]
|
E. coli K5/in vitro
|
|
EcF11_1398
|
kpsU
|
0.0018 |
−4.78 |
blood,PC |
Metabolism (lipopolysaccharide biosynthesis) |
Capsular polysaccharide exporter [73]
|
E. coli K5/in vitro
|
|
EcF11_1399
|
kpsD
|
0.0067 |
−1.95 |
blood,PC |
Hypothetical |
Capsular polysaccharide exporter [74]
|
E. coli K5/in vitro
|
|
EcF11_1400
|
kpsE
|
0.0006 |
−3.40 |
blood,PC |
Metabolism (lipopolysaccharide biosynthesis) |
Capsular polysaccharide exporter [57]
|
E. coli
|
|
|
|
|
|
|
|
Capsule production and adhesion/invasion of host cells [75]
|
Campylobacter jejuni/in vitro and tissue culture |
|
EcF11_1401
|
kpsF
|
0.0192 |
−2.66 |
blood,PC |
Metabolism (lipopolysaccharide biosynthesis) |
Capsular polysaccharide exporter [76]
|
E. coli K1/in vitro
|
|
EcF11_0979
|
wzzB
|
0.0480 |
−2.39 |
blood,PC |
Metabolism (lipopolysaccharide biosynthesis) |
Regulation of O-antigen chain length [77]
|
Salmonella typhimurium and Shigella flexneri/in vitro
|
|
Nutrient utilization
|
EcF11_3352
|
manA
|
0.0024 |
−3.20 |
blood,PC |
Metabolism (fructose and mannose metabolism) |
Mannose utilization, exopolysaccharide structure, biofilm formation and virulence [78]
|
Photorhabdus Luminescens/in vitro and in vivo insect model |
|
EcF11_2113
|
fitD
|
0.0048 |
−2.87 |
blood |
Environmental interactions (transporter) |
Faciliates iron uptake [79]
|
various E. coli/in vitro
|
|
EcF11_4915
|
eutJ
|
0.0191 |
−2.14 |
blood |
Unclassified |
Utilization of ethanolamine as a carbon source [80]
|
Salmonella typhimurium/in vitro
|
|
EcF11_4920
|
eutT
|
0.0096 |
−2.49 |
blood |
Metabolism (porphyrin and chlorophyll metabolism) |
Utilization of ethanolamine as a carbon and nitrogen source [81]
|
Salmonella enterica/in vitro
|
|
Other
|
EcF11_0498
|
tehA
|
0.0188 |
−1.68 |
blood |
Unclassified |
Resistance to antiseptics and disinfectants [82]
|
E. coli K12 lab strain/in vitro
|
|
EcF11_2210
|
tieB, senB
|
0.0002 |
−2.81 |
blood |
Hypothetical |
Entertoxin produced by E. coli and Shigella
[83]
|
EIEC/ex vivo rabbit ileum |
|
EcF11_3975
|
ompR
|
0.0164 |
−1.97 |
blood |
Environmental interactions (two-component system) |
Osmotic stress resistance and fitness in a mouse urinary tract infection model [84]
|
UPEC/in vitro and in vivo mouse model |
|
EcF11_2727
|
potD
|
0.0063 |
−1.44 |
PC |
Environmental interactions (transporter) |
Polyamine surface protein required for virulence [85]
|
Streptococcus pneumoniae/in vivo mouse model |
