Table 2. Patient and tumour characteristics.
Premenopausal (n = 13) | Postmenopausal (n = 29a) | ||
---|---|---|---|
Median age (range), y | 41 (31-49) | 61 (44-81) | |
IHC ER, n | ER+ | 7 | 20 |
ER- | 6 | 9 | |
IHC PR, n | PR+ | 7 | 17 |
PR- | 6 | 12 | |
MLPA, EGFR/HER1, n | Ampl* | 0 | 1 |
Non-ampl | 13 | 25 | |
MLPA, HER2, n | Amplb | 5 | 4 |
Non-ampl | 8 | 22 |
Abbreviations: IHC, Immunohistochemistry; ER, estrogen receptor; PR, progesterone receptor
a Normal tissue was not available for MLPA and mRNA analyses from one patient and tumour tissues were not available from two other patients
b More than 2 alleles of either HER2 or EGFR were considered amplified.