Table 4. Correlations between HER-receptors and NRG1 in normal and breast tumour tissue among postmenopausal women.

			Normal tissue				Tumour
			HER2	HER3	HER4	NRG1	EGFR/HER1	HER2	HER3	HER4	NRG1
Normal tissue	EGFR/HER1	Totala	-0.371	-0.211	-0.197	-0.221	-0.004	0.353	0.307	0.019	0.125
		ER+	-0.183	-0.093	-0.153	-0.154	0.017	0.290	0.222	-0.195	0.082
	HER2	Total		0.616**	0.444*	0.681**	0.199	-0.205	-0.398	-0.103	0.106
		ER+		0.527*	0.488*	0.665**	0.084	-0.001	-0.294	0.106	0.162
	HER3	Total			0.182	0.817**	0.343	-0.197	-0.269	-0.220	0.091
		ER+			0.212	0.911**	0.232	-0.055	-0.137	0.121	0.189
	HER4	Total				0.324	0.135	-0.133	0.193	0.372	0.153
		ER+				0.298	0.096	-0.152	0.216	0.482*	0.127
	NRG1	Total					0.318	-0.031	-0.042	-0.038	0.286
		ER+					0.219	0.008	0.004	0.115	0.215
Tumour	EGFR/HER1	Total						-0.318	-0.450*	-0.334	0.606**
		ER+						-0.271	-0.321	-0.092	0.744**
	HER2	Total							0.532**	0.204	0.076
		ER+							0.564*	0.005	-0.222
	HER3	Total								0.480*	-0.144
		ER+								0.183	-0.327
	HER4	Total									0.244
		ER+									0.253

^a The total group of postmenopausal women and the subgroup of ER+ postmenopausal women.

Spearman rank correlation (two-tailed):

*P≤ 0.05

** P≤ 0.01