Table 5. Correlations of HER-receptors and NRG1 with estrogen levels in normal tissue, tumour tissue and plasma.

				Tumour
				EGFR/HER1	HER2	HER3	HER4	NRG1
Normal tissue	E1		Totala	-0.458*	0.084	0.367	0.276	-0.315
			ER+	-0.498*	0.276	0.423	0.370	-0.236
	E2		Total	-0.556**	0.086	0.412	0.403	-0.473*
			ER+	-0.494*	0.187	0.327	0.291	-0.437
	E1S		Total	0.223	0.081	0.114	0.025	0.196
			ER+	0.211	0.049	0.147	0.004	0.158
Tumour	E1		Total	-0.148	0.136	0.200	0.238	-0.106
			ER+	-0.343	0.257	0.354	0.463	-0.214
	E2		Total	-0.633**	0.289	0.544**	0.298	-0.280
			ER+	-0.676**	0.164	0.261	-0.115	-0.542*
	E1S		Total	0.039	0.057	0.133	0.269	0.336
			ER+	-0.029	0.015	0.220	0.394	0.320
Plasma	E1		Total	-0.509*	0.464*	0.336	0.187	-0.331
			ER+	-0.529*	0.245	0.255	0.047	-0.475
	E2		Total	-0.625**	0.285	0.171	0.215	-0.379
			ER+	-0.647**	0.140	0.206	0.194	-0.436
	E1S		Total	-0.417	0.128	0.115	0.059	-0.257
			ER+	-0.321	-0.069	0.034	0.017	-0.228

^a The total group of postmenopausal women and the subgroup of ER+ postmenopausal women

Spearman rank correlation (two tailed):

* P≤0.05

** P≤0.01