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. 2013 Aug 22;8(8):e73175. doi: 10.1371/journal.pone.0073175

Figure 4. PP242 and erlotinib treatment induce apoptotic cell death.

Figure 4

(A) DLD-1 cells were treated with erlotinib (2 μM) and PP242 (1 μM), alone or in combination, for the indicated hours and then analyzed by flow cytometry. The percentage of sub-G1 apoptotic cells were presented as mean + SD. **, p < 0.01. (B) DLD-1 cells were treated with PP242 (1 μM) and/or erlotinib (2 μM) for the indicated hours and analyzed by western blotting for the cleavage of caspase-3, DFF45 and PARP with the molecular weights of the cleavage products indicated to the right of the panel.