Table 2. Candidate genes located around 100 kb from each significant marker shown in Table 1 *.
Chr. | Markers | Symbols | Descriptions | |
1 | D1S2697† | SPEN | Spen homolog, transcriptional regulator | |
ZBTB17 | Zinc finger and BTB domain containing 17 | |||
C1orf64 | Chromosome 1 open reading frame 64 | |||
HSPB7 | Heat shock 27 kDa protein family, member 7 | |||
CLCNKA | Chloride channel, voltage-sensitive Ka | |||
CLCNKB | Chloride channel, voltage-sensitive Kb | |||
1 | D1S230 | INADL | InaD-like | |
5 | D5S424† | F2R | Coagulation factor II (thrombin) receptor | |
F2RL1 | Coagulation factor II (thrombin) receptor like-1 | |||
S100Z | S100 calcium binding protein Z | |||
CHRBP | Corticotropin releasing hormone binding protein | |||
6 | D6S257† | COL21A1 | Collagen, type XXI, alpha1 | |
12 | D12S368 | KRT | Keratin gene | |
14 | D14S283 | TRAV | T cell receptor alpha variable gene | |
16 | D16S3103† | XYLT1 | Xylosyltransferase I | |
21 | D21S263† | KRTAP | Keratin associated protein gene | |
22 | D22S280 | TIMP3 | Tissue inhibitor of mettaloproteinase 3 | |
SYN3 | Synapsin III |
Chr. = chromosome.
Source: NCBI Map Viewer (http://www.ncbi.nlm.nih.gov/mapview/).
Significant markers associated with HAPE susceptibility, otherwise associated with HAPE resistance.