Table 3.

Associations between combinations of the selected single nucleotide polymorphisms and sleep outcomes.

	Insomnia				Early awakening
	Unadjusted model		Adjusted model		Unadjusted model		Adjusted model
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
CLOCK and AHRR
CLOCK _TT+ AHRR_CC	1.00	Referent	1.00	Referent	1.00	Referent	1.00	Referent
Carriers of CLOCK_T or AHRR_G	0.71	0.49–1.04	0.64	0.43–0.96	0.97	0.66–1.42	0.99	0.67–1.47
Carriers of CLOCK_T and AHRR_G	0.64	0.41–1.01	0.56	0.35–0.89	1.07	0.69–1.66	1.10	0.69–1.74
CLOCK and ARNT
CLOCK _TT+ ARNT_GG	1.00	Referent	1.00	Referent	1.00	Referent	1.00	Referent
Carriers of CLOCK_T or ARNT_C	0.62	0.41–0.95	0.66	0.43–1.01	0.88	0.58–1.33	0.92	0.60–1.41
Carriers of CLOCK_T and ARNT_C	0.67	0.42–1.07	0.67	0.42–1.09	0.97	0.61–1.53	0.99	0.62–1.59
CLOCK and AHR
CLOCK _TT+ AHR_GG	1.00	Referent	1.00	Referent	1.00	Referent	1.00	Referent
Carriers of CLOCK_T or AHR_G	0.90	0.64–1.26	0.95	0.67–1.34	1.36	0.97–1.91	1.38	0.98–1.96
Carriers of CLOCK_T and AHR_A	0.87	0.51–1.47	0.82	0.47–1.43	1.31	0.78–2.19	1.20	0.70–2.05

Abbreviations: OR, odds ratio; CI, confidence interval; CLOCK, circadian locomotor output cycles kaput; AHHR, aryl hydrocarbon receptor repressor; ARNT, aryl hydrocarbon receptor nuclear translocator; AHR, aryl hydrocarbon receptor.

Adjusted OR is adjusted for age (<50/50+ y), race, body mass index (≥30, 25–29, <25), and smoking status (never, former, current).