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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Mol Aspects Med. 2013 Apr 25;34(6):10.1016/j.mam.2013.04.001. doi: 10.1016/j.mam.2013.04.001

Figure 6. Molecular model for PARP1 dependent transcription in development.

Figure 6

1) chromatin remodeling complexes position H2A variants-bearing nucleosomes inside promoter regions; 2) an H2A variants-bearing nucleosome has a greater affinity to PARP1 because of a better surface representation of H3 and H4; therefore, such nucleosome preferentially binds PARP1 and positions it inside promoters; 3) transcriptional factors and/or RNA Polymerase II stimulate phosphorylation of H2AvSer137, thereby activating PARP1 and initiating pADPr production; 4) pADPr induces relaxation in the nucleosome; 5) together, these modifications facilitate transcription through changes in nucleosome structure and facilitate transcription by Pol II.