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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Mol Aspects Med. 2013 Apr 25;34(6):10.1016/j.mam.2013.04.001. doi: 10.1016/j.mam.2013.04.001

Figure 8. A model of protein delivery to Cajal body by PARP1 shuttling.

Figure 8

(1) PARP1 is localized in chromatin and nucleoli. (2) Upon activation, PARP1 automodifies and (3) gains the ability to bind by pADPr a number of proteins with pADPr-binding domain. (4) Whole complex consisting of automodified PARP1 and proteins seated on pADPr migrates into Cajal bodies. (5) In CB, complex is disassembled as a result of cleavage of pADPr and released proteins are recycled. PARP1, pADPr protein-complexes of chromatin and nucleolus are shown. CBm = Cajal body matrix, and Ca = Cajal body cavity.