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. Author manuscript; available in PMC: 2014 Jun 11.
Published in final edited form as: Biochemistry. 2013 May 28;52(23):4003–4013. doi: 10.1021/bi400422a

Figure 1.

Figure 1

Rates of production of toluene metabolites by simple (CPR/CYP2B4 and CPR/CYP1A2) and mixed (CPR/CYP1A2/CYP2B4) systems reconstituted with DLPC. The rates of production of toluene metabolites by simple and mixed reconstituted system in addition to the sum of the rates by the simple systems containing either CYP2B4 or CYP1A2 are shown. The bar labeled “sum” represents the sum of the rates of the simple systems, and would be expected if the combination of P450 proteins in the mixed reconstituted system does not lead to a significant reorganization of the proteins. (A) Benzyl alcohol production. (B) Formation of p-cresol. (C) Formation of o-cresol. Significant differences in the means of the rates obtained with the mixed reconstituted system (n=5 for each condition) when compared to the sum of the rates from the simple reconstituted systems are indicated (*, p < 0.01; **, p < 0.001).