Table 2.

Brain regions identified in the (Voxel [¹¹C]PiB uptake=Plasma Aβ_1-40/Aβ_1-42+APOE ε4 status+(Plasma Aβ_1-40/Aβ_1-42*APOE ε4 status) model (voxel-level threshold of p<0.005 (uncorrected), cluster size≥200 voxels)

Region	Broadmann Area	Peak value coordinates (mm)			Voxel-level		Cluster-level
		x	y	z	T value	pFWE-corr	k	puncorr	pcorr
Left inferior frontal gyrus	BA47	−40	18	−6	3.92	0.713	6152	<0.001	<0.001
Left superior temporal gyrus	BA22	−46	6	−4	3.85	0.774
Left middle frontal gyrus	BA6	−30	12	60	3.81	0.816
Left superior frontal gyrus	BA8	−28	20	56	3.76	0.855
Left precentral gyrus	BA4	−34	−20	52	3.68	0.910
Left insula	BA13	−42	−8	−8	3.58	0.955
Left middle frontal gyrus	BA8	−24	24	50	3.43	0.990
Left middle frontal gyrus	BA10	−36	42	14	3.40	0.993
Left middle temporal gyrus	BA21	−58	−10	−8	3.35	0.996
Left superior frontal gyrus	BA9	−18	48	34	3.29	0.998
Left inferior frontal gyrus	BA45	−50	20	20	3.24	0.999
Left anterior cingulate	BA32	0	44	12	3.23	0.999
Left superior frontal gyrus	BA10	−26	42	30	3.19	1.000
Left medial frontal gyrus	BA10	−2	58	−4	3.17	1.000
Left inferior parietal lobule	BA40	−54	−22	26	3.16	1.000
Left transverse temporal gyrus	BA41	−48	−26	10	3.16	1.000
Left postcentral gyrus	BA40	−48	−34	54	3.73	0.878	273	0.023	0.448
Left inferior parietal lobule	BA40	−36	−52	56	3.54	0.968
Left inferior temporal gyrus	BA20	−64	−8	−26	3.32	0.998	231	0.035	0.586
Left fusiform gyrus	BA20	−62	−4	−28	3.20	1.000
Left middle temporal gyrus	BA21	−54	0	−18	2.84	1.000
Right inferior frontal gyrus	BA47	42	14	−14	3.32	0.998	262	0.026	0.482
Right superior temporal gyrus	BA22	46	0	−4	3.16	1.000
Right sub-gyral	BA13	44	2	−8	3.08	1.000
Right insula	BA13	42	−6	4	2.92	1.000

Abbreviations: p_FWE-corr, Voxel-level p value after family-wise error correction; k, number of voxels in cluster; p_uncorr, Cluster-level uncorrected p value; p_corr, Cluster-level p value after random field theory correction.