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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Xenobiotica. 2013 Apr 25;43(11):973–984. doi: 10.3109/00498254.2013.791410

Figure 1.

Figure 1

Principal components analysis (PCA) scores plots for urines of male and female WT and Tg-2D6 mice from UPLC-ESI-QTOFMS metabolomics in positive-ion mode. (A) Four of each of male WT, female WT, male Tg-2D6 and female Tg-2D6 mice were studied and their 0–24h urines subjected to UPLC-ESI-QTOFMS analysis. For both male and female mice, there was poor clustering and considerable overlap of the scores between the WT and Tg-2D6 mice. (B) Four of each of male WT, female WT, male Tg-2D6 and female Tg-2D6 mice were administered debrisoquine (10 mg/kg p.o.) and their 0–24h urines subjected to UPLC-ESI-QTOFMS analysis. In contrast to the urines from untreated animals, there was a clear separation of scores between the WT and Tg-2D6 male mice.