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Contractility of the DIAm from natural and accelerated aging mice (mean±SE). Specific forces are corrected for physiological cross-sectional area. Both naturally-aged mice at 75% survival (old; n=10) and the BubR1H/H accelerated-aging model (n=4) at ~60% survival displayed less force generating capacity than young mice (n=7). Data analyzed by one-way ANOVA. *Significantly different than young mice.
