| High in trophoblast Lineage cells vs. iPS cells |
CDX2 |
(caudal type homeobox 2) Important functions in early differentiation to trophoblast lineage |
| EGF |
(epidermal growth factor) stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro |
| GATA2 |
(GATA binding protein 2) Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. |
| KRT8 |
(keratin 8) together with KRT18, to be necessary for embryo survival, |
| LIFR |
(leukemia inhibitory factor receptor alpha) Signal-transducing molecule. May have a common pathway with IL6ST. |
| ISL1 |
(ISL LIM homeobox 1) Binds to one of the cis-acting domain of the insulin gene enhancer. |
| IGF2 |
(insulin-like growth factor 2) is influenced by placental lactogen and may play a role in fetal development |
| COL3A1 |
(collagen, type III, alpha 1) Collagen type III occurs in most soft connective tissues along with type I collagen |
| HGF |
(hepatocyte growth factor) acts as growth factor for a broad spectrum of tissues and cell types. |
| GATA3 |
(GATA binding protein 3) an important regulator of T-cell development and plays an important role in endothelial cell biology. |
| GATA4 |
(GATA binding protein 4) Acts as a transcriptional activator of ANF in cooperation with NKX2-5. |
| High in iPS cells vs. Trophoblast lineage cells |
SOX2 |
(SRY (sex determining region Y)-box 2) Critical for early embryogenesis and for embryonic stem cell pluripotency |
| SLAIN1 |
(SLAIN motif family, member 1) stem cell gene |
| ZNF483 |
(zinc finger protein 483) May be involved in transcriptional regulation |
| EPB41 |
(erythrocyte membrane protein band 4.1) tumor suppressor genes in meningioma pathogenesis. |
| LRIG1 |
(leucine-rich repeats and immunoglobulin-like domains) Act as a feedback negative regulator of signaling by receptor tyrosine kinases |
| PRDM14 |
(PR domain containing 14) may suppress expression of differentiation marker genes in human embryonic stem cells |
| POLR3G |
(polymerase (RNA) III (DNA directed) polypeptide G) human embryonic stem cell specific gene |
| CAV1 |
(caveolin 1, caveolae protein) CAV-1 is a transcriptional target of EWS/FLI-1 |
| NANOG |
(Nanog homeobox) Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. |
| SALL4 |
(Sal –like 4) may be a zinc finger transcription factor |
